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As discussed in this issue of Interface, NAC delivers cysteine to the immune system by producing the amino acid glutathione, an essential component of human immune cells. In fact, it is the most generic cellular antioxidant in the body, and because of its antioxidant activity, glutathione is crucial for the immune system to reach its full potential. In addition to the formation of cicylic acids, Nac plays an important role as a precursor to other cellular antioxidants such as the anti-inflammatory peptide thiamine, but also as a precursor to a general body antioxidant, glutathione.
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More research has indicated that maltodextrin promotes the growth of salmonella, which may be responsible for a range of diseases, such as hepatitis B and C. Studies by the US Centers for Disease Control and Prevention (CDC) have also shown that it impairs cellular antibacterial responses and suppresses antimicrobial defense mechanisms in the gut, leading to inflammation and other diseases resulting from an inappropriate immune response to bacteria.
Maltodextrin can be particularly dangerous when present, according to a 2013 study published in the Journal of Nutritional Science and Vitaminology. It is also a possible cause of gastrointestinal problems such as nausea, vomiting, diarrhea and even diarrhea. Another study by researchers at the University of California, San Francisco (UCSF) and the National Institute of Food and Drug Administration (FDA) published research inNutrients in which they found a “gurgling sound” in the stomachs of people with high levels of the substance.
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A 40-year-old woman with trichotillomania responded to a dose of 2400 mg per day, and a 44-year-old woman with a history of nail bites and other symptoms of the disorder responded with doses of 1200 mg / day. In the second case, a 46-month treatment with NAC, administered twice daily for four months, was reported by a 34-year-old man with nail biting symptoms, and in the last case the dose was reported as 1200 mg / day. A 44-year-old elderly woman reported nail bites after four months of treatment with a dose of 1000 mg / day for two weeks, while a 42-week treatment of symptoms with nail bites with a dose of 500 mg.
In addition to the cases described by Odlaug and Grant, Berk et al23 described individuals who were on a treatment protocol for bipolar disorder and responded to treatment with NAC for pathological nail bite. In a study of 75 depressed bipolar patients, 17% of them were given 17 +. Nac for a period of at least four months.
Odlaug and Grant13 reported a 46-year-old woman who responded to treatment with NAC by dosing 1800 mg / day for one week 4. After taking 1000 mg twice a day, she stopped nailing after 4 weeks.
Grant et al20 investigated the efficacy of NAC in 50 patients with trichotillomania in a placebo-controlled study. In this randomized, double-blind, placebo-controlled, and double-blind study, researchers found that the study scale evaluated the efficacy and safety of 600 mg / day for the treatment of tricyclic encephalomyelitis (TCE) in patients.
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Mardikian et al18 investigated the efficacy and safety of the NAC dosage for the treatment of tricyclic encephalomyelitis in patients with trichotillomania in a randomized, double-blind, placebo-controlled, single-dose study. Grant et al conducted a study with 27 pathological players who received or did not receive placebo at a dose of 600 mg / day for 6 weeks.
NAC appears to be a promising and relatively low-risk intervention, although its efficacy and safety in the treatment of tricyclic encephalomyelitis and trichotillomania is not fully understood. Only further research will clarify the safety and efficacy of the NAC dose and its effects on the development and progression of the disease.
At present, NAC seems to be a tool that can be observed and that could play a valuable role in psychiatric medical environments in the future. Only further research will clarify which dose is most beneficial for a particular psychiatric disease and its effects on the development and progression of the disease. If so, this substance may have a promising future as a monotherapy or augmentation strategy, although its long-term safety and efficacy are not clearly understood. It could therefore be an important addition to the arsenal of treatment options for patients with psychiatric disorders.
Consult your doctor before taking any supplements, especially if you are taking any medication or medications and under medical supervision. Side effects of supplements are rare, but please contact your GP immediately in case of an adverse reaction. Consult your doctor before starting strenuous exercises or taking supplements.
Dr. L. Sansone is the founder and chairman of TOO NAC, the world’s largest supplier of organic, natural and organic dietary supplements and a member of the Board of Trustees of the American Academy of Nutrition and Dietetics (AAPD) and the World Health Organization.
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